Traveling toward Athens on U. S. Route 33 from Columbus, Lancaster, Logan, Nelsonville or Meigs County, or on U. S. Route 50 from Parkersburg, Coolville, Stewart, Guysville, Albany, or Vinton County:
Exit on the Route 682/Richland Ave. exit ramp. Then turn right on Richland Ave. and cross the bridge. At the first stoplight (at Ohio University's Convocation Center and Peden Stadium), turn left on Shafer St. Just past OU's baseball stadium, turn left on Hospital Drive at the O'Bleness Medical Park sign. At the first stop sign in the Medical Park, proceed straight ahead for the Emergency Department entrance or turn right for patient and visitor parking and entrances.

Traveling toward Athens on State Route 56 from New Marshfield or State Route 682 from The Plains:
Continue on West Union Street to the Athens County Fairgrounds. Turn right on Hospital Drive at the O'Bleness Medical Park sign.

From downtown Athens:
Travel on West Union Street to Hospital Drive at the O'Bleness Medical Park sign; or travel on Richland Ave. to the stoplight at Shafer Street (at Ohio University's Convocation Center), turn right and proceed to Hospital Drive at the O'Bleness Medical Park sign on the left (just past OU's baseball stadium). At the first stop sign in the Medical Park, proceed straight ahead for the Emergency Department entrance or turn right for patient and visitor parking and entrances.